pathway browser

Keyword Search


Or select a pathway for search

  • Metabolism

    •     Global and overview maps
    Metabolic pathwaysBiosynthesis of secondary metabolitesMicrobial metabolism in diverse environments
    Carbon metabolism2-Oxocarboxylic acid metabolismFatty acid metabolism
    Biosynthesis of amino acidsNucleotide metabolismBiosynthesis of nucleotide sugars
    Biosynthesis of cofactorsDegradation of aromatic compoundsNitrogen cycle
        Carbohydrate metabolism
    Glycolysis / GluconeogenesisCitrate cycle (TCA cycle)Pentose phosphate pathway
    Pentose and glucuronate interconversionsFructose and mannose metabolismGalactose metabolism
    Ascorbate and aldarate metabolismStarch and sucrose metabolismAmino sugar and nucleotide sugar metabolism
    Pyruvate metabolismGlyoxylate and dicarboxylate metabolismPropanoate metabolism
    Butanoate metabolismC5-Branched dibasic acid metabolismInositol phosphate metabolism
        Energy metabolism
    Oxidative phosphorylationPhotosynthesisPhotosynthesis - antenna proteins
    Carbon fixation by Calvin cycleOther carbon fixation pathwaysMethane metabolism
    Nitrogen metabolismSulfur metabolism
        Lipid metabolism
    Fatty acid biosynthesisFatty acid elongationFatty acid degradation
    Cutin, suberine and wax biosynthesisMycolic acid biosynthesisSteroid biosynthesis
    Secondary bile acid biosynthesisSteroid hormone biosynthesisGlycerolipid metabolism
    Glycerophospholipid metabolismEther lipid metabolismSphingolipid metabolism
    Arachidonic acid metabolismLinoleic acid metabolismalpha-Linolenic acid metabolism
    Biosynthesis of unsaturated fatty acids
        Nucleotide metabolism
    Purine metabolismPyrimidine metabolism
        Amino acid metabolism
    Alanine, aspartate and glutamate metabolismGlycine, serine and threonine metabolismCysteine and methionine metabolism
    Valine, leucine and isoleucine degradationValine, leucine and isoleucine biosynthesisLysine biosynthesis
    Lysine degradationArginine biosynthesisArginine and proline metabolism
    Histidine metabolismTyrosine metabolismPhenylalanine metabolism
    Tryptophan metabolismPhenylalanine, tyrosine and tryptophan biosynthesis
        Metabolism of other amino acids
    beta-Alanine metabolismTaurine and hypotaurine metabolismPhosphonate and phosphinate metabolism
    Selenocompound metabolismCyanoamino acid metabolismD-Amino acid metabolism
    Glutathione metabolism
        Glycan biosynthesis and metabolism
    N-Glycan biosynthesisVarious types of N-glycan biosynthesisMannose type O-glycan biosynthesis
    Glycosaminoglycan degradationGlycosylphosphatidylinositol (GPI)-anchor biosynthesisGlycosphingolipid biosynthesis - globo and isoglobo series
    Glycosphingolipid biosynthesis - ganglio seriesOther glycan degradationLipopolysaccharide biosynthesis
    O-Antigen nucleotide sugar biosynthesisPeptidoglycan biosynthesisExopolysaccharide biosynthesis
        Metabolism of cofactors and vitamins
    Thiamine metabolismRiboflavin metabolismVitamin B6 metabolism
    Nicotinate and nicotinamide metabolismPantothenate and CoA biosynthesisBiotin metabolism
    Lipoic acid metabolismFolate biosynthesisOne carbon pool by folate
    Retinol metabolismPorphyrin metabolismUbiquinone and other terpenoid-quinone biosynthesis
        Metabolism of terpenoids and polyketides
    Terpenoid backbone biosynthesisSesquiterpenoid and triterpenoid biosynthesisCarotenoid biosynthesis
    Insect hormone biosynthesisZeatin biosynthesisLimonene degradation
    Pinene, camphor and geraniol degradationBiosynthesis of ansamycinsPolyketide sugar unit biosynthesis
    Biosynthesis of vancomycin group antibiotics
        Biosynthesis of other secondary metabolites
    Indole alkaloid biosynthesisIsoquinoline alkaloid biosynthesisTropane, piperidine and pyridine alkaloid biosynthesis
    Caffeine metabolismBetalain biosynthesisGlucosinolate biosynthesis
    Penicillin and cephalosporin biosynthesisCarbapenem biosynthesisMonobactam biosynthesis
    Streptomycin biosynthesisNeomycin, kanamycin and gentamicin biosynthesisAcarbose and validamycin biosynthesis
    Novobiocin biosynthesisPhenazine biosynthesisProdigiosin biosynthesis
    Aflatoxin biosynthesisBiosynthesis of various plant secondary metabolites
        Xenobiotics biodegradation and metabolism
    Benzoate degradationAminobenzoate degradationFluorobenzoate degradation
    Chloroalkane and chloroalkene degradationChlorocyclohexane and chlorobenzene degradationToluene degradation
    Nitrotoluene degradationEthylbenzene degradationStyrene degradation
    Atrazine degradationCaprolactam degradationDioxin degradation
    Naphthalene degradationPolycyclic aromatic hydrocarbon degradationMetabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450Drug metabolism - other enzymes

  • Genetic Information Processing

    •     Transcription
    RNA polymeraseBasal transcription factorsSpliceosome
        Translation
    RibosomeAminoacyl-tRNA biosynthesisNucleocytoplasmic transport
    mRNA surveillance pathwayRibosome biogenesis in eukaryotes
        Folding, sorting and degradation
    Protein exportProtein processing in endoplasmic reticulumSNARE interactions in vesicular transport
    Ubiquitin mediated proteolysisSulfur relay systemProteasome
    RNA degradation
        Replication and repair
    DNA replicationBase excision repairNucleotide excision repair
    Mismatch repairHomologous recombinationNon-homologous end-joining
    Fanconi anemia pathway
        Chromosome
    ATP-dependent chromatin remodelingPolycomb repressive complex
        Information processing in viruses
    Viral life cycle - HIV-1Virion - Ebolavirus, Lyssavirus and MorbillivirusVirion - Hepatitis viruses
    Virion - Herpesvirus

  • Environmental Information Processing

    •     Membrane transport
    ABC transportersBacterial secretion system
        Signal transduction
    Two-component systemMAPK signaling pathwayMAPK signaling pathway - fly
    MAPK signaling pathway - plantMAPK signaling pathway - yeastErbB signaling pathway
    Ras signaling pathwayRap1 signaling pathwayWnt signaling pathway
    Notch signaling pathwayHedgehog signaling pathwayHedgehog signaling pathway - fly
    TGF-beta signaling pathwayHippo signaling pathwayHippo signaling pathway - fly
    Hippo signaling pathway - multiple speciesVEGF signaling pathwayApelin signaling pathway
    JAK-STAT signaling pathwayNF-kappa B signaling pathwayTNF signaling pathway
    HIF-1 signaling pathwayFoxO signaling pathwayCalcium signaling pathway
    Phosphatidylinositol signaling systemPhospholipase D signaling pathwaySphingolipid signaling pathway
    cAMP signaling pathwaycGMP-PKG signaling pathwayPI3K-Akt signaling pathway
    AMPK signaling pathwaymTOR signaling pathwayPlant hormone signal transduction
        Signaling molecules and interaction
    Neuroactive ligand-receptor interactionECM-receptor interactionCell adhesion molecules

  • Cellular Processes

    •     Transport and catabolism
    EndocytosisPhagosomeLysosome
    PeroxisomeAutophagy - animalAutophagy - yeast
    Autophagy - otherMitophagy - animalMitophagy - yeast
    Efferocytosis
        Cell growth and death
    Cell cycleCell cycle - yeastCell cycle - Caulobacter
    Meiosis - yeastOocyte meiosisApoptosis
    Apoptosis - flyApoptosis - multiple speciesFerroptosis
    Necroptosisp53 signaling pathwayCellular senescence
        Cellular community - eukaryotes
    Focal adhesionAdherens junctionTight junction
    Gap junctionSignaling pathways regulating pluripotency of stem cells
        Cellular community - prokaryotes
    Quorum sensingBiofilm formation - Vibrio choleraeBiofilm formation - Pseudomonas aeruginosa
    Biofilm formation - Escherichia coli
        Cell motility
    Bacterial chemotaxisFlagellar assemblyMotor proteins
    Cytoskeleton in muscle cellsRegulation of actin cytoskeleton

  • Organismal Systems


    •     Immune system
    Platelet activationNeutrophil extracellular trap formationToll-like receptor signaling pathway
    Toll and Imd signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathwayC-type lectin receptor signaling pathwayNatural killer cell mediated cytotoxicity
    Antigen processing and presentationT cell receptor signaling pathwayTh1 and Th2 cell differentiation
    Th17 cell differentiationIL-17 signaling pathwayB cell receptor signaling pathway
    Fc epsilon RI signaling pathwayFc gamma R-mediated phagocytosisLeukocyte transendothelial migration
    Chemokine signaling pathway
        Endocrine system
    Insulin secretionInsulin signaling pathwayGlucagon signaling pathway
    Regulation of lipolysis in adipocytesAdipocytokine signaling pathwayPPAR signaling pathway
    GnRH secretionGnRH signaling pathwayOvarian steroidogenesis
    Estrogen signaling pathwayProgesterone-mediated oocyte maturationProlactin signaling pathway
    Oxytocin signaling pathwayRelaxin signaling pathwayGrowth hormone synthesis, secretion and action
    Thyroid hormone synthesisThyroid hormone signaling pathwayParathyroid hormone synthesis, secretion and action
    MelanogenesisRenin secretionRenin-angiotensin system
    Aldosterone synthesis and secretionCortisol synthesis and secretion
        Circulatory system
    Cardiac muscle contractionAdrenergic signaling in cardiomyocytesVascular smooth muscle contraction
        Digestive system
    Salivary secretionGastric acid secretionPancreatic secretion
    Bile secretionCarbohydrate digestion and absorptionProtein digestion and absorption
    Fat digestion and absorptionCholesterol metabolismVitamin digestion and absorption
    Cobalamin transport and metabolismMineral absorption
        Excretory system
    Vasopressin-regulated water reabsorptionAldosterone-regulated sodium reabsorptionEndocrine and other factor-regulated calcium reabsorption
    Proximal tubule bicarbonate reclamationCollecting duct acid secretion
        Nervous system
    Glutamatergic synapseGABAergic synapseCholinergic synapse
    Dopaminergic synapseSerotonergic synapseLong-term potentiation
    Long-term depressionRetrograde endocannabinoid signalingSynaptic vesicle cycle
    Neurotrophin signaling pathway
        Sensory system
    PhototransductionPhototransduction - flyOlfactory transduction
    Taste transductionInflammatory mediator regulation of TRP channels
        Development and regeneration
    Dorso-ventral axis formationAxon guidanceAxon regeneration
    Osteoclast differentiation
        Aging
    Longevity regulating pathwayLongevity regulating pathway - wormLongevity regulating pathway - multiple species
        Environmental adaptation
    Circadian rhythmCircadian entrainmentCircadian rhythm - plant
    ThermogenesisPlant-pathogen interaction

  • Human Diseases


    •     Cancer: overview
    Pathways in cancerTranscriptional misregulation in cancerMicroRNAs in cancer
    Proteoglycans in cancerChemical carcinogenesis - DNA adductsChemical carcinogenesis - receptor activation
    Chemical carcinogenesis - reactive oxygen speciesViral carcinogenesisCentral carbon metabolism in cancer
    Choline metabolism in cancerPD-L1 expression and PD-1 checkpoint pathway in cancer
        Cancer: specific types
    Colorectal cancerPancreatic cancerHepatocellular carcinoma
    Gastric cancerGliomaThyroid cancer
    Acute myeloid leukemiaChronic myeloid leukemiaBasal cell carcinoma
    MelanomaRenal cell carcinomaBladder cancer
    Prostate cancerEndometrial cancerBreast cancer
    Small cell lung cancerNon-small cell lung cancer
        Infectious disease: viral
    Human T-cell leukemia virus 1 infectionHuman immunodeficiency virus 1 infectionHepatitis B
    Hepatitis CCoronavirus disease - COVID-19Influenza A
    MeaslesHerpes simplex virus 1 infectionHuman cytomegalovirus infection
    Kaposi sarcoma-associated herpesvirus infectionEpstein-Barr virus infectionHuman papillomavirus infection
        Infectious disease: bacterial
    Vibrio cholerae infectionEpithelial cell signaling in Helicobacter pylori infectionPathogenic Escherichia coli infection
    Salmonella infectionShigellosisYersinia infection
    PertussisLegionellosisTuberculosis
    Bacterial invasion of epithelial cells
        Infectious disease: parasitic
    AmoebiasisToxoplasmosisLeishmaniasis
    Chagas diseaseAfrican trypanosomiasis
        Immune disease
    Systemic lupus erythematosusRheumatoid arthritisPrimary immunodeficiency
        Neurodegenerative disease
    Alzheimer diseaseParkinson diseaseAmyotrophic lateral sclerosis
    Huntington diseaseSpinocerebellar ataxiaPrion disease
    Pathways of neurodegeneration - multiple diseases
        Substance dependence
    Cocaine addictionAmphetamine addictionMorphine addiction
    Nicotine addictionAlcoholism
        Cardiovascular disease
    Lipid and atherosclerosisFluid shear stress and atherosclerosisHypertrophic cardiomyopathy
    Arrhythmogenic right ventricular cardiomyopathyDilated cardiomyopathyDiabetic cardiomyopathy
    Viral myocarditis
        Endocrine and metabolic disease
    Type II diabetes mellitusType I diabetes mellitusAlcoholic liver disease
    Non-alcoholic fatty liver diseaseInsulin resistanceAGE-RAGE signaling pathway in diabetic complications
    Cushing syndrome
        Drug resistance: antimicrobial
    beta-Lactam resistanceCationic antimicrobial peptide (CAMP) resistance
        Drug resistance: antineoplastic
    EGFR tyrosine kinase inhibitor resistancePlatinum drug resistanceAntifolate resistance
    Endocrine resistance